Causes and symptoms of sickle cell anemia

Causes and symptoms of sickle cell anemia

Sickle cell anemia is a genetic blood disorder characterized by abnormal, crescent-shaped red blood cells. It is caused by a specific genetic mutation that alters the structure of hemoglobin, the protein responsible for carrying oxygen in red blood cells. According to the World Health Organization, approximately 300,000 infants worldwide are born with sickle cell anemia yearly. These misshapen cells have difficulty passing through small blood vessels, leading to reduced oxygen delivery to tissues and organs. Causes of sickle cell anemia Sickle cell anemia, a genetic blood disorder, has its origins in specific genetic mutations. Understanding these mutations is essential for comprehending the condition’s causes. Genetic inheritance Sickle cell anemia is primarily a hereditary condition rooted in the inheritance of specific genetic mutations. A unique genetic combination occurs when both parents carry an abnormal hemoglobin S (HbS) gene. In this scenario, there’s a 25% chance that their child will inherit two copies of the HbS gene, leading to sickle cell anemia. The sickle cell trait The sickle cell trait comes into play when an individual inherits one HbS gene and one normal hemoglobin gene. Carriers of this trait typically do not experience severe symptoms associated with full-blown sickle cell anemia. However, they can pass this trait on to their children, making it a crucial consideration for family planning and genetic counseling.
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